Molecule Robotics have been realized by using bio molecules such as DNA, proteins, for example in Molecular Robotics Research Project [2012-17, JSPS]; bio molecules, such as DNA or proteins are highly structured and they already have a kind of "intelligence" and adapt to environment change. Hence, we have tried to extract their "ability" and induce Intelligence artificially. We have used well-known DNA reactions, Seesaw gate reaction and we found that DNA molecule can sense concentration of

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... le strand input sequence or quasi-input (including mismatched base pairs and point mutations in the sequence) and chooses higher concentration one; this result shows DNA molecule (short DNA sequence) can adapt to its environment.