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A composite approach towards a complete model of the myosin rod
2015
Proteins: Structure, Function, and Bioinformatics
Sarcomeric myosins have the remarkable ability to form regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. This has been established for over 50 years and yet a molecular model for the thick filament has not been attained. In part this is due to the lack of a detailed molecular model for the coiled-coil that constitutes the myosin rod. The ability to self-assemble resides in the C-terminal section
doi:10.1002/prot.24964
pmid:26573747
pmcid:PMC4715562
fatcat:pylzstchc5gtdlfekzy4d5aclm