Recursive definitions of predicates by means of inference rules are ubiquitous in computer science. They are usually interpreted inductively or coinductively, however there are situations where none of these two options provides the expected meaning. In the thesis we propose a flexible form of coinductive interpretation, based on the notion of corules, able to deal with such situations. In the first part, we define such flexible coinductive interpretation as a fixed point of the standard

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... ce operator lying between the least and the greatest one, and we provide several equivalent proof-theoretic semantics, combining well-founded and non-well-founded derivations. This flexible interpretation nicely subsumes standard inductive and coinductive ones and is naturally associated with a proof principle, which smoothly extends the usual coinduction principle. In the second part, we focus on the problem of modelling infinite behaviour by a big-step operational semantics, which is a paradigmatic example where neither induction nor coinduction provide the desired interpretation. In order to be independent from specific examples, we provide a general, but simple, definition of what a big-step semantics is. Then, we extend it to include also observations, describing the interaction with the environment, thus providing a richer description of the behaviour of programs. In both settings, we show how corules can be successfully adopted to model infinite behaviour, by providing a construction extending a big-step semantics, which as usual only describes finite computations, to a richer one including infinite computations as well. Finally, relying on these constructions, we provide a proof technique to show soundness of a predicate with respect to a big-step semantics. In the third part, we ez face eez the problem of providing an algorithmic support to corules. To this end, we consider the restriction of the flexible coinductive interpretation to regular derivations, analysing again both proof-theoretic and fixed point semant [...]