Comparative Study of Single Dose Per-operative Metronidazole versus Multiple Doses Postoperative Metronidazole in Acute Non-Complicated Appendicitis: A View on Postoperative Complications

Ebtisam K. Salih, Sawsen A. Ibrahem, Ahmed F. Jarullah, Qays A. Hassan
2018 Journal of Krishna Institute of Medical Sciences University  
It has now been proved by researches that per-operative single dose prophylactic antibiotics more crucial in preventing postoperative wound infection in elective cases and clean-contaminated cases like acutely inflamed non-perforated appendicitis. Aim and Objectives: This study investigated the effect of a single dose of metronidazole infusion per-operatively in the treatment of patients undergoing appendicectomy regarding postoperative infective complications. Material and Methods: A total
more » ... er of 111 patients of non-complicated (suppurative and catarrhal) appendicitis enrolled in this prospective study between October 2015 and October 2017. Patients were allocated to two groups in a randomized way. Fifty-one patients in Group A were given a single dose of metronidazole per-operatively. Sixty patients in Group B were given multiple doses of metronidazole postoperatively. Postoperative fever, wound infection, seroma, and intrabdominal collections were compared between both groups. Statistical analysis was performed using Student's t-test and Chi-square test. Results: The patients of both groups were similar in baseline characteristics. No significant difference was found in the rate of postoperative fever and wound infection in both groups. In Group A there were five patients (9%) developed postoperative fever, four of them (7.8%) because of wound infection. In Group B there were six patients (10%) developed postoperative fever, four of them (6.7%) because of wound infection. None of the patients developed seroma or intraabdominal abscesses. Conclusion: Single per-operative dose of metronidazole is quite effective in reducing the incidence of postoperative fever
doaj:a70aeb33891a41cfa3a1e71c5b5ebbaf fatcat:7rlhqikhnrbndkjhtv7cctdn7m