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Developing Dictyostelium cells form evenly sized groups of ϳ2 ؋ 10 4 cells. A secreted 450-kDa protein complex called counting factor (CF) regulates group size by repressing cell-cell adhesion and myosin polymerization and by increasing cAMP-stimulated cAMP production, actin polymerization, and cell motility. We find that CF regulates group size in part by repressing internal glucose levels. Transformants lacking bioactive CF and wild-type cells with extracellular CF depleted by antibodies havedoi:10.1074/jbc.m205635200 pmid:12161440 fatcat:dixzdl63sbbvpgcqpeoa5lhofe