The concomitant use of many drugs by ICU (Intensive Care Unit) patients is almost unavoidable. In these patients, pharmacokinetic drug interactions are terribly possible. This current questionnaire study was designed to evaluate the drug interactions in the ICU patients of Al-Thoura Teaching Hospital in El-beida city, Libya. A questionnaire study was designed and used to collect the requisite knowledge. The present study was conducted in the ICU of Al-Thoura Teaching Hospital affiliated to Omar

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... Al-Mukhtar University, Faculty of Pharmacy. Overall, the data was collected from 450 ICU prescriptions from April 2019 to May 2019. The extent of prevalence and the frequency of potential pharmacokinetic drug interactions were categorized on the basis of the reference text Drug Interaction Facts. There were 300 pharmacokinetic drug interactions in the 450 studied ICU prescriptions that were divided into 64 varieties of pharmacokinetic drug interactions. The first observed drug interaction was between ciprofloxacin and sucralfate. The mechanisms of pharmacokinetic drug interactions were associated with absorption (76.66%), metabolism (18.33%), distribution (3.33%), and elimination (1.66%). There was a direct relationship between the frequency of pharmacokinetic drug interactions and the number of drugs per prescription (r=0.97, p<0.0001). During this survey study, we concluded that the higher number of drugs in prescriptions, the higher number of drug interactions. Therefore, the clinical pharmacists should be aware of the drug interactions in the ICU, and careful drug therapy should be performed if applicable.