Neonatal exposure to estradiol-17β modulates tumour necrosis factor alpha and cyclooxygenase-2 expression in brain and also in ovaries of adult female rats

Radhika Nagamangalam Shridharan, Harshini Krishnagiri, Vijayakumar Govindaraj, SitiKantha Sarangi, Addicam Jagannadha Rao
2016 Hormone Molecular Biology and Clinical Investigation  
AbstractThe sexually dimorphic organization in perinatal rat brain is influenced by steroid hormones. Exposure to high levels of estrogen or endocrine-disrupting compounds during perinatal period may perturb this process, resulting in compromised reproductive physiology and behavior as observed in adult In our recent observation neonatal exposure of the female rats to estradiol-17β resulted in down-regulation of
doi:10.1515/hmbci-2015-0072 pmid:26872318 fatcat:ipmydqpv4jh7lb4tpvwmi4emei