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Dominant interfering alleles define a role for c-Myb in T-cell development
Genes & Development
The transcription activator c-Myb is expressed at high levels in immature thymocytes and during T-cell activation and may be a regulator of T-cell differentiation. To investigate the role of c-Myb in T-cell development, we generated transgenic mice in which two dominant interfering Myb alleles, one a competitive inhibitor of DNA binding, and the other, an active repressor comprising the Myb DNA-binding domain linked to the Drosophila Engrailed transcription repressor domain, were expressed fromdoi:10.1101/gad.8.7.770 pmid:7926766 fatcat:ffoz3punafh6bhtdf2y2epjise