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Glomerular galactose-deficient IgA1 expression analysis in pediatric patients with glomerular diseases
2020
Scientific Reports
Galactose-deficient IgA1 (Gd-IgA1) is important in the pathogenesis of IgA nephropathy (IgAN). A Gd-IgA1-specific monoclonal antibody (KM55) has revealed glomerular Gd-IgA1 deposition solely in patients with IgAN and IgA vasculitis with nephritis (IgAV-N). However, this specificity is controversial and has not been demonstrated in pediatric patients. Here, we conducted double-immunofluorescence staining of IgA and Gd-IgA1 in 60 pediatric patients with various glomerular diseases. We divided
doi:10.1038/s41598-020-71101-y
pmid:32820208
fatcat:er3pnf3tqvgblbigd3ytsdi73a