Stereoselective Suzuki Coupling Reaction of an α-Bromo-α-fluoro-β-lactam

Akira Ando, Atsushi Tarui, Erina Miyata, Ayumi Tanaka, Kazuyuki Sato, Masaaki Omote
2014 Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry  
A new strategy has been developed for the synthesis of α-aryl-α-fluoro-β-lactams via the Suzuki cross-coupling of α-bromoα-fluoro-β-lactam with a range of different aryl-(9-BBN) reagents. This method provides facile access to multisubstituted α-fluoro-β-lactams in a diastereoselective manner. The synthetic utility of α-bromo-α-fluoroβ-lactam has been demonstrated by the arylation of α-bromo-α-fluoroβ-lactam.
doi:10.1055/s-0034-1379637 fatcat:ikhxdgkl6vekbj2gt45fxov6vu