Halogenated (F, Cl, Br, I) Anabolic Steroids and their Biological Activities

Anna Kilimnik, Tatyana A. Gloriozova, Valery M. Dembitsky
2017 International Journal of Current Research in Biosciences and Plant Biology  
A b s t r a c t A r t i c l e I n f o The present review describes the biological activities of synthetic anabolic halogenated (F, Cl, Br and I) steroids. About sixty biologically active halogenated steroids have shown confirmed anti-inflammatory, estrogenic, anabolic, gynecological disorders, anti-arthritic, antineoplastic, and other activities. The structures and reported and predicted activities of halogenated steroids are available. With the computer programme PASS and based on
more » ... sed on structure-activity relationships (SAR), some additional activities are also predicted, which point towards new possible applications of these lipids. This review emphasizes the role of halogenated steroids as an important source and potential leads for drug discovery and they are of great interest to chemists, physicians, biologists, pharmacologists and the pharmaceutical industry.
doi:10.20546/ijcrbp.2017.412.006 fatcat:4rxlgsvy4bddvgp5e5xzu6dqoy