Comprehensive Visual Rating Scale on MRI: Application to prodromal Alzheimer's disease

Jae Kyung Chung, Jae-Won Jang, Alzheimer's Disease Neuroimaging Initiative
2021 Annals of Geriatric Medicine and Research  
A comprehensive visual rating scale (CVRS) using brain magnetic resonance imaging (MRI) was previously developed to evaluate structural changes in the brains of older patients. This study investigated the usefulness of the CVRS in predicting dementia with Alzheimer's disease (AD) in patients with prodromal AD. Methods We included 189 patients with prodromal AD with available data from the Alzheimer's Disease Neuroimaging Initiative study. We assessed all patients using CVRS and assessed their
more » ... ogression to AD dementia over 3 years of longitudinal follow-up. Survival analysis was performed using the Cox proportional hazards model to analyze the hazard ratios (HRs) of the CVRS for progression to AD dementia. Results Among 189 patients with prodromal AD, 61 (32.3%) progressed to dementia. The mean baseline CVRS scores differed significantly between the stable and progressive groups (9.9 ± 5.1 vs. 12.4 ± 4.9, p=0.002). An initial high CVRS score was an independent risk factor for the progression to AD dementia (HR 1.110, 95% confidence interval [CI] 1.043-1.182). Conclusions The baseline CVRS score predicted the progression to dementia in patients with prodromal AD, indicating its independent association with longitudinal cognitive decline.
doi:10.4235/agmr.21.0010 pmid:33715339 pmcid:PMC8024168 fatcat:qpreunqrz5fe7kku3ug3ufybra