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The iron-responsive element binding protein. Purification, cloning, and regulation in rat liver
1992
Journal of Biological Chemistry
The iron-responsive element binding protein (IRE-BP) is a cytosolic protein that binds a highly conserved sequence in the untranslated regions of mRNAs involved in iron metabolism including ferritin, transferrin receptor, and erythroid 5-aminolevulinate acid synthase. This conserved sequence is termed the iron-responsive element and is necessary for the post-transcriptional regulation of these mRNAs by iron. The rat liver IRE-BP was purified to homogeneity by chromatographic methods and partial
pmid:1527027
fatcat:xfqjqeqlnrg2laiufxyjykme6u