Efficacy and safety of self-expanding metallic stent placement followed by neoadjuvant chemotherapy and scheduled surgery for treatment of obstructing left-sided colonic cancer [post]

2019 unpublished
BACKGROUND: Stoma is reported to be frequent in self-expanding metallic stent (SEMS) treated patients with obstructing left-sided colon cancer than in those with non-obstructing surgery. This study aimed to evaluate the safety and feasibility of SEMS followed by neoadjuvant chemotherapy prior to elective surgery for obstructing left-sided colon cancer. METHODS: Eleven consecutive patients with obstructing left-sided colon cancer between May 2014 and November 2015 were included retrospectively.
more » ... d retrospectively. All patients received SEMS followed by neoadjuvant chemotherapy. The primary outcome measure was stoma and laparoscopic surgery. RESULTS: Chemotherapy was with two cycles of CAPOX (54.5%) or three cycles mFOLFOX6 (45.5%). Median serum albumin and hemoglobin levels before surgery were significantly higher than before neoadjuvant chemotherapy (p = 0.01 and p = 0.008 respectively) and before SEMS (p = 0.01 and p = 0.003 respectively). Median bowel wall thickness proximal to the upper edge of tumor was significantly more before neoadjuvant chemotherapy than before stent (p = 0.003), and significantly less before surgery than before neoadjuvant chemotherapy (p = 0.003). No patient underwent stoma creation. Laparoscopic surgery was performed in nine (81.8%) patients. No local recurrence or metastases developed over median cancer-specific follow-up of 44 months (range, 37-55 months). CONCLUSION: SEMS followed by neoadjuvant chemotherapy prior to elective surgery appears to be safe and well tolerated in patients with obstructing left-sided colon cancer. Background Approximately 10%-30% of newly diagnosed colorectal cancer patients present with acute intestinal obstruction requiring urgent surgical treatment. 1 The risk of obstruction, which varies depending on the tumor site, is about 75% located in the left colon. 2 Postoperative mortality is much higher with emergency surgery than with elective surgery (15%-30% vs. 1%-5%), and the morbidity rate after emergency surgery (40%-50%) is twice that of elective surgery. 1,3 A population-based prospective study by the French Association of Surgery showed that emergency surgery is an independent risk factor for mortality after colorectal resection, and that outcomes are worse in patients with poor general condition at presentation. 4 Although performing intraoperative
doi:10.21203/rs.2.14773/v2 fatcat:qvrmr6cdlzhflhxwy6iaam4euq