Patient predictors of poor drug sensitive tuberculosis treatment outcomes in Kyiv Oblast, Ukraine

Omowunmi Aibana, Andrej Slavuckij, Mariya Bachmaha, Viatcheslav Krasiuk, Natasha Rybak, Timothy P. Flanigan, Vasyl Petrenko, Megan B. Murray
2018 F1000Research  
Ukraine has high rates of poor treatment outcomes among drug Background sensitive tuberculosis (DSTB) patients, while global treatment success rates for DSTB remain high. We evaluated baseline patient factors as predictors of poor DSTB treatment outcomes. : We conducted a retrospective analysis of new drug sensitive Methods pulmonary TB patients treated in Kyiv Oblast, Ukraine between November 2012 and October 2014. We defined good treatment outcomes as cure or completion and poor outcomes as
more » ... poor outcomes as death, default (lost to follow up) or treatment failure. We performed logistic regression analyses, using routine program data, to identify baseline patient factors associated with poor outcomes. Among 302 patients, 193 (63.9%) experienced good treatment Results: outcomes while 39 (12.9%) failed treatment, 34 (11.3%) died, and 30 (9.9%) were lost to follow up. In the multivariate analysis, HIV positive patients on anti-retroviral therapy (ART) [OR 3.50; 95% CI 1.46 -8.42; p 0.005] or without ART (OR 4.12; 95% CI 1.36 -12.43; p 0.01) were at increased risk of poor outcomes. Frequent alcohol use (OR 1.81; 95% CI 0.93 -3.55; p 0.08) and smear positivity (OR 1.75; 95% CI 1.03 -2.97; p 0.04) were also associated with poor treatment outcomes. High rates of poor outcomes among patients with newly Conclusions: diagnosed drug sensitive TB in Kyiv Oblast, Ukraine highlight the urgent need for programmatic interventions, especially aimed at patients with the highest risk of poor outcomes.
doi:10.12688/f1000research.12687.2 fatcat:h5p35ojnebfrlhqjxp4n4i5qeu