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Expression weighted cell type enrichments reveal genetic and cellular nature of major brain disorders
The cell types that trigger the primary pathology in many brain diseases remain largely unknown. One route to understanding the primary pathological cell type for a particular disease is to identify the cells expressing susceptibility genes. Although this is straightforward for monogenic conditions where the causative mutation may alter expression of a cell type specific marker, methods are required for the common polygenic disorders. We developed the Expression Weighted Cell Type Enrichmentdoi:10.1101/032680 fatcat:55gxfubntvdgno6xwtco7t32v4