Synthesis of 2-oxoquinoline-3-carboxamide of ampicillin and amoxicillin as inhibitors of penicillin binding protein 1A of pseudomonas aeruginosa

Jayant Shelke, Gangadhar Meshram, Prabhkar Dongre
2012 Acta Poloniae Pharmaceutica - Drug Research  
A series of ampicillin and amoxicillin derivatives were prepared by N-acylation with N1-substituted 1, 2-dihydro-2-oxoquinoline carboxylic acids by Schotten-Baumann procedure and evaluated as inhibitors of Pseudomonas aeruginosa using molecular docking study. Most of the derivatives showed remarkableactivity against Gram positive and Gram negative bacteria in vitro.
pmid:22876604 fatcat:gcnc2sv7qnefzoxahbzqt53xd4