The Dynamic Roles of Cell-Surface Receptors in Melanoma Development [chapter]

Dong Fang, Meenhard Herlyn
From Melanocytes to Melanoma  
Cell-surface receptors on melanocytic cells change dramatically during transformation. These molecules facilitate adhesive functions and modulate growth, survival, and invasion. In this review, we focus on cadherins for cell-cell adhesion and frizzled (Fzd) receptors for growth control. Both receptors activate the -catenin pathway, which is critical for melanocyte differentiation and melanoma progression. Cadherins are physically associated with receptor tyrosine kinases that mediate growth
more » ... mediate growth signals. The switch from epithelial cadherin in melanocytes to neural cadherin in melanoma cells appears to profoundly change cell-signaling partners for each cell type.
doi:10.1007/978-1-59259-994-3_9 fatcat:nnrruizbovh3hkip2pgntdkkyy