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Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection
Journal of Experimental Medicine
The human placenta is a dynamic organ that modulates physiological adaptations to pregnancy. To define the immunological signature of the human placenta, we performed unbiased profiling of secreted immune factors from human chorionic villi isolated from placentas at mid and late stages of pregnancy. We show that placental trophoblasts constitutively secrete the inflammasome-associated cytokines IL-1β and IL-18, which is blocked by NLRP3 inflammasome inhibitors and occurs without detectabledoi:10.1084/jem.20200649 pmid:32976558 fatcat:4nw6okbwmngdpnsik7mvfufiiq