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The bacterium Lactobacillus plantarum is prevalent in animal guts and is widely regarded as beneficial and probiotic. D. Fast et al. (mBio 9:e01114-18, 2018, https://doi.org/10.1128/mBio.01114-18) make the surprising discovery that L. plantarum reduces the life span of Drosophila melanogaster and link this effect with the loss and weakened proliferation of stem cells in the Drosophila gut. These results are apparently at odds with published evidence for beneficial effects of L. plantarum,doi:10.1128/mbio.01758-18 fatcat:a3ljhb65sfchjhh2jg67rvc25m