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Multi-drug resistance in the treatments of autoimmune diseases
2006
Japanese Journal of Clinical Immunology
Although corticosteroids and immunosuppressants are widely used for the treatments of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), we often experience patients who are resistant to these treatments. P glycoprotein (P gp) of membrane transporters, a product of the multiple drug resistance (MDR) 1 gene, plays a pivotal role in the acquisition of drug resistance. However, the relevance of MDR 1 and P gp to resting and activated lymphocyte,
doi:10.2177/jsci.29.319
pmid:17075191
fatcat:xqzem3aegjhhhesbwhhoelfwfu