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We suggest a method implemented in a computer program, immodestly dubbed TSUNAMI, that allows us to compare two homologous protein subfamilies with respect to the distribution of substitution rates along sequences. This study furthers our earlier work on a wavelet model of rate variation (1). The current approach allows sensitive detection of subtle discordances in the selection patterns between two protein subfamilies. In addition to performing fast computation of the maximum posteriordoi:10.1142/9789814447362_0021 fatcat:jxg33dd5xjgw5kaqhqxirdyxwa