Purpose: Allergic diseases have been increased in Korea. The aim of this study was to investigate the changes of sensitization rate to inhalant allergens over 10 years in children with allergic diseases from a tertiary referral hospital. Methods: Skin prick tests were done in total 2,225 children in 2000, 2005, and 2010. Changes of skin reactivity to 12 major inhalant allergens, including Tree pollen mixture I (Alder, Elm, Hazel, Poplar, Willow), Tree pollen mixture II (Beech, Birch, Oak, Plane

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... tree), Dermatophagoides pteronyssinus, Dermatophagoides farina, Alternaria, cat dander, and dog dander were investigated. Results: The sensitization rates to Tree pollen mixture I and II were increased as 5.0%, 6.8% in 2000, 8.5%, 9.8% in 2005, and 14.8%, 17.3% in 2010, respectively (trend P< 0.001, P< 0.001, respectively). And the sensitization rates to D. pteronyssinus cat dander and dog dander were changed as 55%, 4.8%, 4.8% in 2000, 62.2%, 11.9%, 28% in 2005, and 63.1%, 12.7%, 16.7% in 2010, respectively. The distribution of sensitized pollens was oak (12.8%), beech (12.4%), pine (10.3%), birch (10%), hazel (9.6%), alder (8%), elder (6.9%), elm (5.4%) in the study of 2010. When allergen/histamine ratio was compared, rates of strong sensitization over 4+ to tree pollen were increased. Conclusion: The sensitization rates to inhalant allergens were increased in children with asthma or allergic rhinitis from a tertiary referral hospital in Seoul over last 10 years. Especially, an increase in the degree of skin reactivity was observed in cat dander, dog dander, and tree pollens. The studies to investigate the etiology of this increase and prevention will be needed. (Allergy Asthma Respir Dis 2014;2:97-102) 서 론 지난 수십 년 동안 알레르기질환은 전 세계적으로 꾸준히 증가 해 왔으며, 1-3) 국내에서도 이에 대한 보고가 여러 차례 있었다. 4-9) 이 렇게 알레르기질환이 증가하는 원인으로는 대기오염의 증가, 10) 생 활패턴의 변화, 11) 기후 변화로 인한 화분 등의 실외 알레르겐, 집먼 지진드기, 개 비듬, 고양이 비듬 등의 실내 알레르겐 증가 등을 들 수 있다. 12) 특히 최근 국내에서 화분량 및 화분 식물의 생태 변화에 대한 보고가 있었는데, 기후 변화에 의해 개화 기간이 길어지면서 국내에서도 화분에 대한 노출량이 많아졌고, 목초류(grass) 및 잡 Allergy Asthma Respir Dis 2(2):97-102, May 2014 http://dx.