Automaton Models of Computational Genetic Regulatory Networks with Combinatorial Gene-Protein Logical Interactions

Peter C.Y. Chen, Yulin Weng
2009 2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing  
This article presents a formal framework for modeling computational genetic regulatory networks as automata, with multi-threshold protein concentration and combinatorial logical gene-protein interactions. By computing the intersection of the languages generated by these automata we obtain the complete set of pathways in a gene network. We illustrate the effectiveness of our framework in the modeling of (i) morphogenesis in Arabidopsis and (ii) regulation in phage λ.
doi:10.1109/ijcbs.2009.94 dblp:conf/ijcbs/ChenW09 fatcat:prhjv33g6retlk3h65dsyv4lki