Design, synthesis and biological evaluation of valepotriate derivatives as novel antitumor agents

Bo Zhang, Ruiying Guo, Yongzhou Hu, Xiaowu Dong, Nengming Lin, Xiaoyang Dai, Honghai Wu, Shenglin Ma, Bo Yang
2017 RSC Advances  
A series of valepotriate derivatives with novel skeleton were synthesized from commercial available genipin. Among them, 1e exhibited significant anti-proliferation activity against H1975 cells by inducing mitochondrion-mediated apoptosis.
doi:10.1039/c6ra27478a fatcat:uv3clryrmnespoosoj5dbukike