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Effect of methionine load on homocysteine levels, lipid peroxidation and DNA damage in rats receiving ethanol
Brazilian Journal of Pharmaceutical Sciences
Changes in the metabolism of methionine can cause hyperhomocysteinemia, inducing a triad of atherosclerosis, hypertension, and increased oxidative stress. The generation of free radicals and oxidative damage to DNA is important in the liver damage caused by ethanol. In this study, the effect of methionine overload associated or otherwise with acute administration of ethanol on homocysteine values, damage to DNA, lipoperoxidation and vitamin E was evaluated. Thirty rats were divided into 3doi:10.1590/s1984-82502009000400014 fatcat:3r2dyzwm5reifc7nweevhlvegy