Flow-Injection Amperometric Determination of Tacrine based on Ion Transfer across a Water–Plasticized Polymeric Membrane Interface

Joaquin Ortuño, C. Rueda
2007 Sensors  
A flow-injection pulse amperometric method for determining tacrine, based on ion transfer across a plasticized poly(vinyl chloride) (PVC) membrane, was developed. A four-electrode potentiostat with ohmic drop compensation was used, while a flow-through cell incorporated the four electrodes and the membrane, which contained tetrabutylammonium tetraphenylborate. The influence of the applied potential and of the flow-injection variables on the determination of tacrine was studied. In the selected
more » ... d. In the selected conditions, a linear relationship between peak height and tacrine concentration was found up to 4x10 -5 M tacrine. The detection limit was 1x10 -7 M. Good repeatability was obtained. Some common ions and pharmaceutical excipients did not interfere.
doi:10.3390/s7071185 fatcat:bbrejbopbjctvcikhcpsgwdlnq