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A composite-likelihood approach for identifying polymorphisms that are potentially directly associated with disease
2008
European Journal of Human Genetics
If a linkage signal can be fully accounted for by the association of a particular polymorphism with the disease, this polymorphism may be the sole causal variant in the region. On the other hand, if the linkage signal exceeds that explained by the association, different or additional directly associated loci must exist in the region. Several methods have been proposed for testing the hypothesis that association with a particular candidate single-nucleotide polymorphism (SNP) can explain an
doi:10.1038/ejhg.2008.242
pmid:19092770
pmcid:PMC2687550
fatcat:wcet4gvbbbdijk27enczlhiqfm