The paper based on Communicology of Mazu belief, the theory of religious and cultural communication, to discuss the spread process of Mazu belief culture in South Taiwan. This paper discusses the way of communication firstly. The second part analyzes the routes of communication. Finally, we describe the sources of communication, including immigrants, monks, officials, gentry and merchants, etc. Let us have a clear understanding of the communication and diffusion of Mazu belief culture in southern Taiwan.