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Application of large-scale targeted sequencing to distinguish multiple lung primary tumors from intrapulmonary metastases
The effective differentiation between multiple primary lung tumors (MPs) and intrapulmonary metastases (IMs) in patients is imperative to discover the exact disease stage and to select the most appropriate treatment. In this study, the authors was to evaluate the efficacy and validity of large-scale targeted sequencing (LSTS) as a supplement to estimate whether multifocal lung cancers (MLCs) are primary or metastatic. Targeted sequencing of 520 cancer-related oncogenes was performed on 36doi:10.1038/s41598-020-75935-4 pmid:33139840 fatcat:t3sddnozvjeplhstxh6ucjla5e