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Cerebral cortex structure in prodromal Huntington disease
2010
Neurobiology of Disease
Neuroimaging studies of subjects who are gene-expanded for Huntington Disease, but not yet diagnosed (termed prodromal HD), report that the cortex is "spared," despite the decrement in striatal and cerebral white-matter volume. Measurement of whole-cortex volume can mask more subtle, but potentially clinically relevant regional changes in volume, thinning, or surface area. The current study addressed this limitation by evaluating cortical morphology of 523 prodromal HD subjects. Participants
doi:10.1016/j.nbd.2010.07.014
pmid:20688164
pmcid:PMC2955824
fatcat:2ho6dgavbbcdja3wpyc6yayl5m