THE ROLE OF PROTEIN OXIDATIVE MODIFICATION IN REDOX-REGULATION OF CASPASE-3 ACTIVITY IN BLOOD LYMPHOCYTES DURING OXIDATIVE STRESS IN VITRO

O. L. Nosareva, Ye. A. Stepovaya, N. V. Ryazantseva, Ye. V. Shakhristova, O. N. Vesnina, V. V. Novitsky
2016 Bûlleten' Sibirskoj Mediciny  
1 Ñèáèðñêèé ãîñóäàðñòâåííûé ìåäèöèíñêèé óíèâåðñèòåò, ã. Òîìñê 2 Ñèáèðñêèé ôåäåðàëüíûé óíèâåðñèòåò, ã. Êðàñíîÿðñê 3 Êðàñíîÿðñêèé ãîñóäàðñòâåííûé ìåäèöèíñêèé óíèâåðñèòåò èì. ïðîô. Â.Ô. Âîéíî-ßñåíåöêîãî, ã. Êðàñíîÿðñê РЕЗЮМЕ Â îñíîâå ïàòîãåíåçà ìíîãèõ ðàñïðîñòðàíåííûõ è ñîöèàëüíî-çíà÷èìûõ çàáîëåâàíèé ëåaeèò ôîðìèðîâàíèå îêèñëèòåëüíîãî ñòðåññà. Ëèìôîöèòû êðîâè ÿâëÿþòñÿ êëåòêàìè, îáåñïå÷èâàþùèìè èììó-íîëîãè÷åñêèé êîíòðîëü îðãàíèçìà.  ðåçóëüòàòå ïðîèñõîäèò êîíòàêò ëèìôîöèòîâ êðîâè ñ ðàçëè÷íûìè
more » ... ñ ðàçëè÷íûìè ýíäîãåííûìè è ýêçîãåííûìè ôàêòîðàìè, ÷òî ìîaeåò ïðèâîäèòü ê èíòåíñèôèêàöèè ïðîäóêöèè àêòèâíûõ ôîðì êèñëîðîäà, îêèñëèòåëüíîé ìîäèôèêàöèè ìàêðîìîëåêóë è èçìåíåíèþ âûaeèâàåìîñòè êëåòîê. Àêòóàëüíûì ÿâëÿåòñÿ ðàñøèðåíèå è óãëóáëåíèå ôóíäàìåíòàëüíûõ çíàíèé îá îñîáåííîñòÿõ ðåãóëÿöèè àïîïòîçà ëèìôîöèòîâ êðîâè. ABSTRACT The formation of oxidative stress lies at the heart of many frequent and socially-important diseases. Blood lymphocytes are the cells which provide immunological control of our organism. As a result of their function implementation blood lymphocytes contact with different endogenic and exogenic factors, which can lead to active oxygen species production activation, macromolecules oxidative modification and to cell survival alteration. At the present time it is essential to expand and deepen the fundamental knowledge of blood lymphocytes apoptosis regulation peculiarities.
doi:10.20538/1682-0363-2015-14-6-61-67 fatcat:d7nkyvc5z5e3xice2llqezmf2m