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The natural history of type 1A diabetes
2008
Arquivos brasileiros de endocrinologia e metabologia
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We can now predict the development of Type 1A (Immune Mediated) diabetes primarily through the determination of four biochemically characterized islet autoantibodies [insulin, GAD65, IA-2 (ICA512) and (Znt8)]. Prediction is possible because beta-cell destruction is chronically progressive and very slow in most, but not all individuals. We can also prevent type 1A diabetes in animal models and a major goal is the prevention of type 1A diabetes in man with multiple clinical trials underway.
doi:10.1590/s0004-27302008000200002
pmid:18438525
fatcat:hzxkxt2yo5gwfaxb27ivy7iz4u