Helicobacter pylori being worldwide in distribution can cause several gastric complications such as gastritis, peptic ulcer diseases and gastric cancer. The risk for the development of gastric complications may be decreased by eradicating the bacteria by antibiotic treatment. However, high rate of treatment failure has been observed, primarily because of the point mutations observed in the antibiotic targets. In this review, we have briefly summarized the resistance mediated by the point mutations of common antibiotic targets.