Comparing the sensitivity of pyridoxal-5-phosphate, homocysteine and neopterin in coronary heart disease

Vera Rudzite, Edite Jurika, Uldis Kalnins, Andrejs Erglis, Karlis Trusinskis, Sanda Jegere, Barbara Frick, Dietmar Fuchs
2002 Pteridines  
Blood serum pyridoxal-5-phosphate, homocysteine and neopterin concentrations have been examined in 30 healthy individuals and 87 patients with coronary heart disease, verified by coronary angiography. Patients have been observed before percutaneus transluminal coronary angioplasty (31 patients with one-artery disease, 30 with two-or three-artery disease, 26 with restenosis). Results suggest that lowered serum pyridoxal-5-phosphate concentrations were an earlier indicator of coronary heart
more » ... oronary heart disease than increase of serum homocysteine concentration above 15 μπιοΙ/L. An increase of serum neopterin concentration appears to be a marker of coronary disease activity rather than a marker of the presence of coronary heart disease.
doi:10.1515/pteridines.2002.13.3.100 fatcat:udxvsii6uvgrtpc6g3lidbdsma