Phynium pubinerve Blume is a original plant of North Sulawesi that is widely used by local residents as a wrapper of rice. Plant leaves contain alkaloids and terpenoids. Alkaloids compounds have long been studied and used in the treatment of antidiabetes. The mechanism of action alkaloids in lowering blood glucose is by increasing insulin secretion, increasing glucose uptake by adipose tissue and skeletal muscle tissue, inhibits intestinal glucose absorption and inhibits hepatic glucose

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... on. So even terpenoida compounds. The antidiabetic activity of terpenes has been widely recognized and has the same properties as alkaloids. The aim of this study was to know the effect of Phrynium pubinerve Blume leaf on the effect in decreasing blood glucose level on alloxan-induced diabetes mellitus rats. The design of this study was laboratory experimental with post-test only control group design. The experiment was conducted in vivo using experimental animals. Blood glucose levels were determined every day for 10 days. Dose Phrynium pubinerve Blume seeds dry extract administered orally. Used of 30 male rats divided into negative control group, positive control with Glibenlamide 0,65 mg/Kg BW, the P1-P4 group treated with leaf extract with doses was 625; 250; 2500 and 4500 mg / KgBB. Testing results showing that four levels dose extract elusan leaf able to decreasing blood glucose levels, after gave elusan leaf extract treatment for 10 days. Data analysis result-test, using with T-test there was significantly on dose elusan leaf 2500 mg/kg body weight (P3) on the decreasing blood glucose levels on white rattus has α value = 0,000. Conclusion: Results of research showing that dose was very effected that is intervention treatment elusan leaf dose of 2500mg/kgBW. Suggestion so that can be done continued research of acut toxicity test. Word Key: Phynium pubinerve Blume, blood glucose, aloxan.