Transplantation strategies to promote repair of the injured spinal cord

Mary Bartlett Bunge, Damien D. Pearse
2003 Journal of rehabilitation research and development  
This review describes the results of the transplantation of Schwann cells and olfactory ensheathing glia in combination with other interventions. The complete transection injury model was used to test the combination of Schwann cell bridges with methylprednisolone, neurotrophins, or olfactory ensheathing glia. The contusion injury model was used to compare Schwann cell and olfactory ensheathing glia transplantation and to examine the results of combining Schwann cell transplants with elevated
more » ... nts with elevated levels of cyclic adenosine monophosphate. The combination strategies were more effective than cell transplantation alone. The improved regeneration response usually involved a reduction in secondary tissue loss, axonal regeneration from brainstem neurons, an increase in myelinated fibers in the transplant, the exit of regenerated fibers from the transplant into the contiguous cord, and an improvement in locomotor function. Abbreviations: ATP = adenosine triphosphate, BBB = Basso, Beattie, Bresnahan rating scale, BDNF = brain-derived neurotrophic factor, cAMP = cyclic adenosine monophosphate, cDNA = complementary deoxyribonucleic acid, CNS = central nervous system, CREB = cAMP-response element binding protein, db-cAMP = di-butyryl cAMP, GTP = guanosine triphosphate, MAG = myelin-associated glycoprotein, NF-κB = nuclear factor kappa B, NT-3 = neurotrophin-3, OEG = olfactory ensheathing glia, PKA = protein kinase A, SC = Schwann cell, TNF-α = tumor necrosis factor-α, WGA-HRP = wheat germ agglutinin horseradish peroxydase.
doi:10.1682/jrrd.2003.08.0055 fatcat:hdrm2ekjandqllk4op5dnmvdqq