A retrospective assessment of the effectiveness of the application of a combination of radio-frequency radiation (needle lifting) and injections of platelet-enriched autologous human plasma was made in the correction of involuntary changes in the skin of the face and neck of 57 patients aged 40-65 years with signs of chronic aging and photodamage of the skin. Dermatological status was assessed before and after the reparative correction of involuntary changes in the skin through morphostructural

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... analysis of the skin using the method of ultrasonography, visual analog scales, photography, studying the quality of life, and assessing patients' satisfaction with the used treatment. To objectify the results, they were compared according to age: in the group of patients up to 49 years old and over 49 years of age. As a result of the application of the combined treatment method, the degree of manifestation of clinical signs of skin aging (the qualitative characteristics of the skin and the degree of wrinkles) markedly decreased, which contributed to an improvement in the quality of life of this category of patients. More than 90% of patients regardless of age noted good/very good efficacy and comfort of the combined method. Combined method of correction of involuntary changes in the face and neck skin, based on a combination of cellular technology with platelet activation by autologous thrombin and effect on the skin by needle lifting is a highly effective method of correcting involuntary skin changes.