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Background Feature extraction of protein sequences is widely used in various research areas related to protein analysis, such as protein similarity analysis and prediction of protein functions or interactions. Results In this study, we introduce FEGS (Feature Extraction based on Graphical and Statistical features), a novel feature extraction model of protein sequences, by developing a new technique for graphical representation of protein sequences based on the physicochemical properties ofdoi:10.1186/s12859-021-04223-3 pmid:34078264 fatcat:za4lzippenf5xaq2lis6fnld4u