Imaging Microglia and Astrocytes non-invasively using Diffusion MRI [article]

Raquel Garcia-Hernandez, Alejandro Trouve Carpena, Mark Drakesmith, Kristen Koller, Derek K. Jones, Santiago Canals, Silvia De Santis
2020 bioRxiv   pre-print
We present a strategy to image neuroinflammation in grey matter using diffusion-weighted MRI. We demonstrate that the MRI signal carries the fingerprint of microglia and astrocytes activation, and that specific signatures from each glia population can be extracted in vivo. In addition, we prove the translational value of the approach in a cohort of healthy humans. This framework will aid basic and clinical research to clarify the role of inflammation during lifespan.
doi:10.1101/2020.02.07.938910 fatcat:o3gy7frhgbhrlji24qkbnqptzu