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Analysis of prepulse inhibition in mouse lines overexpressing 22q11.2 orthologues
2009
International Journal of Neuropsychopharmacology
Animal models have been useful in elucidating the genetic basis of the cognitive and behavioural phenotypes associated with the 22q11.2 microdeletions. Loss-of-function models have implicated a number of genes as playing a role in prepulse inhibition (PPI) of the startle response. Here, we report the generation and initial analysis of bacterial artificial chromosome (BAC) transgenic (Tg) mice, overexpressing genes from within the 22q11.2 locus. We used engineered BAC constructs to generate Tg
doi:10.1017/s1461145709000492
pmid:19519974
fatcat:oiksg2lhhrejnpywvjix4n4f3i