Thyroid hormones are the body's primary regular of normal development of organs. High and low levels of Thyroid hormones alter the balance of metabolism of oxygen in human cells and stimulate the over production of free radicals which associated with many biochemical abnormalities. The study conducted on (40) newly diagnosed hypothyroidism females (Group 1), (40) treated hypothyroidism with L-Thyroxin for more than six months (Group 2), (40) newly diagnosed hyperthyroidism females (Group 3),

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... (40) treated hyperthyroidism with carbamizole for more than six months (Group 4). The patient's biochemical parameters were compared with that for (40) apparently healthy control. Fasting blood samples were taken from all participant and analyzed for peroxynitrite, ceruloplasimin (CP), vitamins C (vit. C), Albumin (Alb), and glutathione (GSH). The levels of peroxynitrite increased significantly in all patients, pre and post treatment compared to healthy control. Ceruloplasimin, in all patients, pre and post treatment, showed no significant differences from that of control group. Albumin was found to be compatible with control group apart from untreated hypothyroidism (Group 1) who showed significantly lower value. The level of vitamin C showed significantly low levels pretreatment for both patient groups. The level showed no significant differences from control after treatment, while, serum Glutathione concentration showed a significant decrease in all groups in comparison with the control.