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In designing longitudinal studies, researchers must determine the number of subjects to randomize based on the power to detect a clinically meaningful treatment difference and a proposed analysis plan. In this paper, we present formulas for sample size estimation and an assessment of statistical power for a two-treatment repeated measures design allowing for subject attrition. These formulas can be used for comparing two treatment groups across time in terms of linear contrasts. Subjects aredoi:10.2202/1557-4679.1098 pmid:22462117 fatcat:t5gsbxrwwbfdxik3wynpzrny2i