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Hematology/Oncology and Stem Cell Therapy
Thrombotic thrombocytopenic purpura (TTP) is a multisystem disorder characterized by microvascular aggregation of platelets and fibrin strands causing thrombocytopenia, microangiopathic hemolytic anemia, and organ dysfunction. TTP can develop as a result of a deficiency in ADAMTS13 enzyme activity due to either a genetic defect or, more commonly, the development of anti-ADAMTS13 autoantibodies. TTP can also be associated with pregnancy, organ transplant, lupus, infections, and drugs. Here, wedoi:10.1016/j.hemonc.2015.11.003 pmid:26684918 fatcat:jhrhz3hkwbcnhpvpvbkmo5izly