Prevalence and Risk Factors for Bone Loss in Rheumatoid Arthritis Patients from South China: modeled by three methods [post]

Zhuoran Hu, Lei Zhang, Zhiming Lin, Changlin Zhao, Shuiming Xu, He Lin, Jiejing Zhang, Wenjie Li, Yongliang Chu
2021 unpublished
Background. To explore the prevalence of bone loss among patients with rheumatoid arthritis and healthy controls and further explored the risk factors for osteopenia and osteoporosis of RA patients. Methods. A cross-sectional survey was undertaken in four hospitals in different districts in South China. Case records, laboratory tests, and bone mineral density (BMD) results were included. Multivariable logistic regression analysis, least absolute shrinkage, selection operator (LASSO), and random
more » ... (LASSO), and random forest (RF) was for exploring the risk factors for osteopenia or osteoporosis in RA patients.Results. Four hundred five patients with RA and 198 HC were included. RA patients had lower BMD in almost detective sites than healthy controls; the decline of lumbar spine BMD was earlier than HC. RA patients were more likely to comorbid with osteopenia and osteoporosis (p for trend <0.001) in the lumbar spine than HC. Higher serum 25-hydroxyvitamin D3 level and using tumor necrosis factor inhibitor in the last year, aging, lower body mass index, and increased serum uric acid were associated with bone loss.Conclusions. RA patients were more prone and earlier to have bone loss than HC. More attention should be paid to measuring BMD in RA patients aging with lower BMI or hyperuricemia. Besides, serum vitamin D and all three detective sites are recommended to check routinely. TNFi usage in the last year might benefit bone mass.
doi:10.21203/rs.3.rs-289906/v1 fatcat:eyi4orusmved5jkhd7fbac6d6y