Effects of a novel seven-species probiotic against oropharyngeal bacterial infestation

2017 Journal of Clinical and Analytical Medicine  
Aim: Ventilator-associated pneumonia results from invasion of the lower respiratory tract and lung parenchyma by microorganisms. Our study aimed to investigate the efficacy of a new probiotic combination containing 7 bacterial species against oropharyngeal bacterial infestation in adult trauma intensive care unit patients. Material and Method: One hundred and fifty patients were placed in the two treatment groups by computerized random allocation in a 1:1 ratio and received either probiotics or
more » ... ither probiotics or placebo. Oropharyngeal cultures were taken on the 1st (before the intervention), 4th, and 6th days of admission. Results: The culture results of the 1st, 4th, and 6th days were comparable, and no statistically significant difference was noticed in the two arms of the study. Discussion: Based on the results of our study, administration of probiotics to alter early oropharyngeal cavity infestation with a potentially pathogenic microorganism in adult trauma patients admitted in Intensive Care Unit appears to be non-efficacious, even when a 7-species combination is used.
doi:10.4328/jcam.5472 fatcat:j27aez63vrc5tig3yreg6e5mpm