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Fluid therapy is one of the most important treatments in patients with traumatic brain injury (TBI) as both hypoand hypervolaemia can cause harm. The main goals of fluid therapy for patients with TBI are to optimize cerebral perfusion and to maintain adequate cerebral oxygenation. The avoidance of cerebral oedema is clearly essential. The current weight of evidence in the published literature suggests that albumin therapy is harmful and plasma substitutes have failed to demonstrate superioritydoi:10.5603/ait.a2017.0067 pmid:29165777 fatcat:24hejr6oxfdxhc6nap4dju7nqe