Descriptive Epidemiology of Malignant primary osteosarcoma in Tunisia 1980-2016

Feryel Letaief Ksontini, Fatma Guermazi, Meddeb Khadija, Mokrani Amina, Yahiaoui Yosra, Gabsi Azza, Rais Henda, Chraiet Nesrine, Ayadi Mouna, Mezlini Amel
2018 Asian Pacific Journal of Cancer Care  
Osteosarcoma is a rare malignant tumor of the mesenchymal tissue that accounts for 5% of all malignant tumors in children and teenager. The purpose of our study was to describe the epidemiological and evolutionary characteristics of osteosarcoma in Tunisia.Methods: It's a retrospective study performed in the Oncology Department of Salah Azaiez Institute from January 1980 to December 2016. We analyzed records of 200 cases of patients with primary high-grade osteosarcoma.Results: The mean
more » ... s: The mean incidence was 6 cases per year. The mean age at the time of diagnosis was 19 years with a slight male predominance (55%). The distribution had a single peak during adolescence and a plateau during adulthood. The average consultation period was 3.4 months. The most common reasons for consultation were the pain (82%), followed by swelling (74%), trauma (10%), fracture (6.5%), and functional impairment (5.5%). Mean tumor size was 11 cm. Preferred site was long bones in young patients and flat bones in elderly ones. Common osteosarcoma was the most frequent (85%). Overall survival and progression-free survival at 5 years were respectively 78% and 90.5%.Conclusion: In summary, this study is a large national population-based incidence report of osteosarcoma in Tunisia.
doi:10.31557/apjcc.2018.3.4.81 fatcat:zcff57qrrbfd5ayxpdbiy7oane