Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin

Maja Karaman, Kristina Tesanovic, Aleksandra Novakovic, Dragica Jakovljevic, Ljiljana Janjusevic, Filip Sibul, Boris Pejin
2018 Figshare  
In vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR
more » ... d. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry.
doi:10.6084/m9.figshare.7356761 fatcat:iuh2dfo5xbdubbw76grsjohs4e