Research Article Tissue and serum expression of microRNAs miR-34a, miR-143, miR-145 and miR-335 is not correlated with tumor progression in meningiomas

M.S.T. Rosa, F. Pansani, F.O. Buono, M.F.B.M. Tiezzi, L.P. Turra, F.S. Lizarte Neto, P.C. Novais, M.F.G.S. Tazima, F.M. Peria, V.M. Carneiro, M.L.A. Cirino, L.F. Tirapelli (+3 others)
2020 Genetics and Molecular Research  
profile of miRNAs associated with estrogen and progesterone receptor pathways in grade I, II and III meningiomas. Tissue and blood samples from 40 patients with grade I, II and III meningiomas were investigated using real-time PCR to analyze the expression of the miRNAs miR-34a, miR-143, miR-145 and miR-335. The miRNAs miR-34a and miR-145 had significantly lower expression in the tumor tissue samples of grade II meningiomas when compared to grades I and III. We did not observe significant
more » ... e significant differences in miRNA expression in the blood samples. We concluded that the expression of these miRNAs is not correlated with tumor progression in meningiomas.
doi:10.4238/gmr18080 fatcat:cmimsowrtzckdgusglc7htaxf4